Identification of microRNA expression signature for the diagnosis and prognosis of cervical squamous cell carcinoma.
作者： Esra Bozgeyik , Neslihan Bayramoglu Tepe , Zehra Bozdag
DOI: 10.1016/J.PRP.2020.153159
关键词: Carcinoma 、 Cervical Squamous Cell Carcinoma 、 Internal medicine 、 Multivariate analysis 、 Oncology 、 Survival analysis 、 Cervical cancer 、 microRNA 、 Medicine 、 Cancer 、 Diagnostic Factor
摘要: Abstract Cervical cancer is the fourth leading cause of death among women globally. The prognosis cervical patients differs considerably, and clinical outcomes are difficult to predict. Given significant roles miRNAs in human cancers, identification novel reliable miRNA biomarkers important for targeted therapy. In present study, we aimed reveal biological significance miR-200a, miR-423, miR-34a, miR-193a, miR-455 diagnosis their association with patients. Distinct expression profiles formalin-fixed paraffin-embedded tissue samples healthy controls were evaluated using qRT-PCR. We identified miR-455, miR-34a significantly downregulated squamous cell carcinoma tissues compared normal cervix from controls. Both confers a promising diagnostic factor while miR-200a showed no ROC analysis. Notably, low was markedly associated poor overall survival as revealed by Kaplan-Meier Also, univariate multivariate analysis indicated an independent prognostic factor. Consequently, our results underline importance distinct carcinoma.
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