RECOMBINANT WRL 105 STRAIN LIVE ATTENUATED INFLUENZA VACCINE

作者： C.A. Morris , V.M. Stealey , D.S. Freestone , P.R. Oliver

DOI: 10.1016/S0140-6736(75)90670-4

关键词: Immunology 、 Virology 、 Antibody 、 Antigen 、 Vaccination 、 Immunogenicity 、 Medicine 、 Live attenuated influenza vaccine 、 Placebo 、 Incidence (epidemiology) 、 Recombinant DNA 、 General Medicine

摘要: Abstract The immunogenicity, reactivity, and transmissibility of recombinant WRL 105 (H3N2) (A/Okuda/57 × A/Finland/4/74) strain live attenuated influenza virus vaccine were studied in adult male volunteers a residential community rural England. Thirteen received single dose 10 7.0 E.I.D. 50 administered as nose drops, twelve placebo. Nine (82%) eleven with initial antibody titres ≤1/96 showed significant response to vaccination, but there was no evidence transmission those who incidence nature reactions similar shown confer protection against natural infection exhibiting antigenic characteristics equivalent A/ Scotland/840/74.

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