Live attenuated vaccines against influenza; an historical review

摘要: Live attenuated vaccines administered directly to the respiratory tract offer promise of providing more effective immunity against influenza than subunit or split inactivated vaccines. Evidence has accumulated in recent years that immunological responses relevant both prevention and recovery from are best induced by natural infection. The ease with which genes viruses reassort when two infect a single cell been exploited as means rapidly producing Donor strains have shown extensive testing be fully used co-infect cells contemporary epidemic produce reassortants required degree avirulence surface antigens strain. Reassortants prepared cold-adapted mutants A B widely clinical trials United States Russia over many well tolerated adults children highly efficacious.