Regulation of chloramphenicol synthesis in Streptomyces sp. 3022a. Properties of arylamine synthetase, an enzyme involved in antibiotic biosynthesis
作者： A. Jones , D. W. S. Westlake
DOI: 10.1139/M74-247
关键词: Streptomyces 、 Aromatic amine 、 Enzyme Repression 、 Chorismic acid 、 Biochemistry 、 Enzyme 、 Chloramphenicol 、 Microbiology 、 Cell-free system 、 Biology 、 Biosynthesis 、 Immunology 、 Applied Microbiology and Biotechnology 、 Genetics 、 Molecular biology 、 General Medicine
摘要: A new arylamine synthetase activity has been demonstrated in Streptomyces sp. 3022a when grown under chloramphenicol-producing conditions. The enzyme has several characteristics which distinguish it from anthranilate synthetase. It converts chorismic acid to an, as yet, unidentified aromatic amine easily separable from anthranilic and p-aminobenzoic acids. This arylamine synthetase was absent from strains of Streptomyces sp. 3022a, which were incapable of chloramphenicol production. The addition of chloramphenicol to growing cultures repressed arylamine synthetase but not anthranilate synthetase activity. The role of arylamine synthetase in the control and regulation of chloramphenicol biosynthesis is discussed.
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