Regulation of chorismate-derived antibiotic production.

摘要: Publisher Summary Antibiotic production is a dispensable function of the producing cell, which characteristic plasmic-borne traits, such as sex, metal resistance, pathogenicity, and drug resistance. The pattern antibiotic in any medium strongly influenced by growth rate organism. Contact aurodox-producing Streptomyces goldiniensis with its necessary for expression resistance to aurodox. Aurodox inhibits both protein synthesis release elongation factor Tu from ribosomes Mutants resistant inhibition aurodox are also feedback biosynthesis this antibiotic. Cross-regulation histidine B. subtilis mediated through tryptophan. Both anthranilic acid stimulate tryptophan production, represses all enzymes pathway. In auxotroph, elevated levels anthranilate synthetase divert chorismic keep intracellular pool level branch point intermediate sufficiently low so that chloramphenicol pathway not induced.