Single-nucleotide polymorphism-mass array reveals commonly deleted regions at 3p22 and 3p14.2 associate with poor clinical outcome in esophageal squamous cell carcinoma.
作者： Yan Ru Qin , Li Fu , Pak C. Sham , Dora L.W. Kwong , Cai Lei Zhu
DOI: 10.1002/IJC.23577
关键词: Cancer 、 SNP 、 Cancer research 、 Esophageal cancer 、 Metastasis 、 Single-nucleotide polymorphism 、 Tumor suppressor gene 、 Carcinoma 、 Biology 、 Loss of heterozygosity 、 Pathology
摘要: Esophageal squamous cell carcinoma (ESCC) is one of the most common solid tumors in world with poor prognosis. Deletion chromosome 3p frequent chromosomal alterations ESCC, suggesting existence or more tumor suppressor genes (TSGs) at this region. In present study, a recently developed high-throughput and high-resolution technology, single-nucleotide polymorphism (SNP)-mass array, was applied to investigate loss heterozygosity on 100 primary ESCC cases 386 SNP markers. Four commonly deleted regions (CDRs) 3p26.3, 3p22, 3p21.3 3p14.2 were identified. Absent down-regulated expression several candidate TSGs, including CHL1, PCAF, RBMS3, PLCD1 CACNA2D3, detected lines. Moreover, deletions CDRs 2 4 correlated advanced stage deletion CDR2 associated metastasis ESCC. Our findings provided evidence that minimal containing potential TSGs may contribute pathogenesis esophageal cancer.
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