Emerging antibody-based therapeutic strategies for bladder cancer: A systematic review
作者： Rita Azevedo , José Alexandre Ferreira , Andreia Peixoto , Manuel Neves , Nuno Sousa
DOI: 10.1016/J.JCONREL.2015.07.002
关键词: Cancer 、 Oncology 、 Urinary system 、 Targeted therapy 、 Malignancy 、 Disease 、 Clinical trial 、 Internal medicine 、 Medicine 、 Immunology 、 Immunotherapy 、 Bladder cancer
摘要: Bladder cancer is the most common malignancy of urinary tract, presents highest recurrence rate among solid tumors and second leading cause death in genitourinary cancers. Despite recent advances understanding pathophysiology disease, management bladder patients remains a clinically challenging problem. Particularly, invading muscularis propria disseminated disease are often not responsive to currently available therapeutic approaches, which include surgery conventional chemotherapy. Antibody-based strategies have become an established treatment option for over decade several types cancer. However, has remained mostly “orphan disease” regarding introduction these novel therapeutics, been translated few improvements overall survival. In order shift this paradigm, clinical studies involving antibody-based targeting prominent cancer-related biomolecular pathways immunological mediators ongoing. This systematic review explores therapeutics undergoing trial discusses future perspectives field, envisaging development more effective guided therapeutics.
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