Prospective evaluation of clinically relevant type B hyperlactatemia in dogs with cancer.

摘要: Background: Cancer is considered a cause of type B hyperlactatemia in dogs. However, studies evaluating cancer as clinically relevant (>2.5 mmol/L) are lacking. cells have higher lactate production because increased aerobic glycolysis, known the “Warburg effect.” The mechanisms through which glycolysis occurs not well elucidated, but neoplasia may via this process. Objectives: To determine if malignant tumors dogs associated with (>2.5 mmol/L). Animals: Thirty-seven client-owned tumors: 22 hematopoietic and 15 solid tumors. Methods: Histology was used to confirm diagnosis (cytology adequate for lymphoma). Confounding conditions were excluded. Lactate measurements immediately performed on free-flow jugular whole blood samples using LactatePro analyzer. Results: All had concentrations <2.5 mmol/L. Mean concentration 1.09 mmol/L. 0.95 1.19 mmol/L, respectively. Dogs lymphoma (n = 18) mean 1.15 mmol/L. Conclusions: Malignant hyperlactatemia. Therefore, cancer-related uncommon, should prompt careful investigation causes other than cancer.