Smad4 restoration leads to a suppression of Wnt/β-catenin signaling activity and migration capacity in human colon carcinoma cells
作者： Xiaoxiao Tian , Hao Du , Xiangsheng Fu , Kang Li , Aimin Li
DOI: 10.1016/J.BBRC.2009.01.124
关键词: Cell biology 、 Wnt signaling pathway 、 Tumor suppressor gene 、 Cadherin 、 Cytoplasm 、 Metastasis 、 Cell migration 、 Biology 、 Colorectal cancer 、 Beta-catenin 、 Biophysics 、 Biochemistry 、 Molecular biology
摘要: … signal activity in SW480 cells by down-regulating β-catenin … of β-catenin/Tcf target genes, such as claudin-1 and MMP-7. … and the most important tight junction for barrier function in …
elsevier.com
sci-hub.se 参考文章(20)
Ugo Cavallaro, Gerhard Christofori, Cell adhesion and signalling by cadherins and Ig-CAMs in cancer Nature Reviews Cancer. ,vol. 4, pp. 118- 132 ,(2004) , 10.1038/NRC1276
Daniel J. Satterwhite, Kristi L. Neufeld, TGF-β Targets the Wnt Pathway Components, APC and β-catenin, as Mv1Lu Cells Undergo Cell Cycle Arrest Cell Cycle. ,vol. 3, pp. 1067- 1071 ,(2004) , 10.4161/CC.3.8.1072
Andreas Stockinger, Andreas Eger, Julia Wolf, Hartmut Beug, Roland Foisner, E-cadherin regulates cell growth by modulating proliferation-dependent β-catenin transcriptional activity Journal of Cell Biology. ,vol. 154, pp. 1185- 1196 ,(2001) , 10.1083/JCB.200104036
Alex Gregorieff, Hans Clevers, Wnt signaling in the intestinal epithelium: from endoderm to cancer Genes & Development. ,vol. 19, pp. 877- 890 ,(2005) , 10.1101/GAD.1295405
Nicole Müller, Anke Reinacher-Schick, Stephan Baldus, Jolanda van Hengel, Geert Berx, Anke Baar, Frans van Roy, Wolff Schmiegel, Irmgard Schwarte-Waldhoff, Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells. Oncogene. ,vol. 21, pp. 6049- 6058 ,(2002) , 10.1038/SJ.ONC.1205766
Karl Willert, Roel Nusse, β-catenin: a key mediator of Wnt signaling Current Opinion in Genetics & Development. ,vol. 8, pp. 95- 102 ,(1998) , 10.1016/S0959-437X(98)80068-3
N. Miwa, M. Furuse, S. Tsukita, N. Niikawa, Y. Nakamura, Y. Furukawa, Involvement of claudin-1 in the beta-catenin/Tcf signaling pathway and its frequent upregulation in human colorectal cancers. Oncology Research. ,vol. 12, pp. 469- 476 ,(2001) , 10.3727/096504001108747477
Cara J. Gottardi, Ellen Wong, Barry M. Gumbiner, E-Cadherin Suppresses Cellular Transformation by Inhibiting β-Catenin Signaling in an Adhesion-Independent Manner Journal of Cell Biology. ,vol. 153, pp. 1049- 1060 ,(2001) , 10.1083/JCB.153.5.1049
Paul Polakis, The oncogenic activation of β-catenin Current Opinion in Genetics & Development. ,vol. 9, pp. 15- 21 ,(1999) , 10.1016/S0959-437X(99)80003-3
Michiko Miyaki, Toshio Kuroki, Role of Smad4 (DPC4) inactivation in human cancer. Biochemical and Biophysical Research Communications. ,vol. 306, pp. 799- 804 ,(2003) , 10.1016/S0006-291X(03)01066-0