Salinomycin kills cancer stem cells by sequestering iron in lysosomes
作者： Trang Thi Mai , Ahmed Hamaï , Antje Hienzsch , Tatiana Cañeque , Sebastian Müller
DOI: 10.1038/NCHEM.2778
关键词: Chemistry 、 In vitro 、 Organelle 、 Programmed cell death 、 Ferritin 、 Biochemistry 、 Cancer research 、 Salinomycin 、 Cancer stem cell 、 Reactive oxygen species 、 Metastasis
摘要: … 6), which could take place as a direct consequence of lysosomal iron targeting we have observed. Hijacking iron with small molecules such as ironomycin (AM5) may thus provide the …
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