Cognition in older adults with bipolar disorder versus major depressive disorder

摘要: In late life, bipolar disorder (BD) and major depressive (MDD) are associated with cognitive dysfunction even when patients euthymic (1–6). Both disorders also increased rates of dementia (7, 8). addition to impaired function, these may interfere everyday functional abilities (9). Whether BD MDD have similar or different profiles levels impairment in older age is not clear. Identifying whether there relevant differences help understanding the neurobiology illnesses developing specific interventions for prevent, halt, remediate decline. For example, deficits memory require treatments than executive function. Additionally, if both comparable but differing ability, might need consider targets other cognition enhance function (10). In this report, our primary aim was examine overall patterns MDD. Our main hypothesis that among adults, would be a pattern deficits, primarily information processing speed function; however, level more severe individuals BD. We predicted instrumental activities daily living (IADLs) directly related performance, most significantly Information Processing Speed Executive Function, IADLs subjects These hypotheses were based on prior reports current literature concerning neurodegeneration (11). Exploratory analyses conducted relationship lifetime history psychosis duration illness since longer been worse (12).