Neurocognitive and neuroimaging predictors of clinical outcome in bipolar disorder.

摘要: Historically, bipolar disorder has been conceptualized as a disease involving episodic rather than chronic dysfunction. However, increasing evidence indicates that is associated with substantial inter-episode psychosocial and vocational impairment. Here we review the contributions of neurocognitive deficits structural functional neuroanatomic alterations to observed impairments. In particular, compelling now suggests impairments, particularly in areas attention, processing speed, memory, are outcome. Although investigation neural correlates disability only its nascent stages, preliminary white matter abnormalities may be predictive poor A better understanding relationship between neuroimaging assays outcome potential improve current treatment options provide targets for new strategies disorder.