Chemotherapy of bacterial infections

摘要: The synthesis of thirteen (N4) amino-substituted sulphanilamide compounds thiozal and related derivatives is described. None them showed any activity in experimentalstreptococcal andpneumococcal infections mice. Five acridine the above group have also been Though some possessed considerable thestreptococcal infections, they were inactive inpneumococcal infections. It apparent that for pronounced antibacterial action heterocyclic ring should be substituted sulphonamide radical leaving a free amino group, which appears to play significant, but as yet not perfectly understood, role mechanism therapeutic action.