SOME PHARMACOLOGICAL AND TOXICOLOGICAL PROPERTIES OF SULFANILAMIDE AND BENZYLSULFANILAMIDE

摘要: 1. In oral toxicity experiments the l.d. 50 of sulfanilamide (suspended in gum acacia) was 4.8 grams per kilogram mice, 6.2 rats and 3 rabbits. Oral administration benzylsulfanilamide did not produce death at any dose level. 2. The cumulative determined mice by feeding single daily doses for 10 consecutive days. Under these conditions remained practically unchanged, while that increased, being 3.5 4.2 rats. 3. chronic studied with stomach tube to 120 days, rabbits 32 days dogs Benzylsulfanilamide nontoxic, became more pronounced. Animals were sacrificed after 10, 20, 30, examined anatomically histologically. organs animals found be normal, showed a pronounced enlargement spleen occasional degenerative changes liver kidney. 4. Nervous symptoms such as ataxia, clonic convulsions paralysis, which are regularly produced large sulfanilamide, benzylsulfanilamide. 5. No significant circulatory respiratory system either drug. After lethal occurs from failure. 6. While up 2 no on water diuresis rats, larger (3 4 kilogram) markedly decreased urinary output. observed 7. Administration amounts fluid together or following increases its toxicity. This is probably due an increased rate absorption output, since within one hour blood concentration receiving considerably greater than control animals. 8. liberation fed determined. may sufficient account therapeutics properties reported 9. If therapeutic effect solely clinical usefulness would appear limited infections will respond favorably moderate blood.