Neonatal exposure to low dose corticosterone persistently modulates hippocampal mineralocorticoid receptor expression and improves locomotor/exploratory behaviour in a mouse model of Rett syndrome.
作者： Bianca De Filippis , Laura Ricceri , Andrea Fuso , Giovanni Laviola
DOI: 10.1016/J.NEUROPHARM.2012.05.048
关键词: Glucocorticoid receptor 、 Psychology 、 Glucocorticoid 、 Hippocampus 、 MECP2 、 Internal medicine 、 Endocrinology 、 Mineralocorticoid receptor 、 Rett syndrome 、 Neurodevelopmental disorder 、 Corticosterone
摘要: … in a RTT mouse model, thus contrasting RTT-related … hippocampal MR gene expression in RTT mice is also provided. As a whole, these results confirm the usefulness of this RTT …
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E. Ronald De Kloet, Hormones, brain and stress Endocrine Regulations. ,vol. 37, pp. 51- 68 ,(2003)
Richard Z. Chen, Schahram Akbarian, Matthew Tudor, Rudolf Jaenisch, Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice Nature Genetics. ,vol. 27, pp. 327- 331 ,(2001) , 10.1038/85906
Xiao-Ming Ou, John M. Storring, Neena Kushwaha, Paul R. Albert, Heterodimerization of Mineralocorticoid and Glucocorticoid Receptors at a Novel Negative Response Element of the 5-HT1A Receptor Gene Journal of Biological Chemistry. ,vol. 276, pp. 14299- 14307 ,(2001) , 10.1074/JBC.M005363200
Pierre-Antoine Defossez, Irina Stancheva, Biological functions of methyl-CpG-binding proteins. Progress in Molecular Biology and Translational Science. ,vol. 101, pp. 377- 398 ,(2011) , 10.1016/B978-0-12-387685-0.00012-3
Van Oers, De Kloet, Levine, Persistent effects of maternal deprivation on HPA regulation can be reversed by feeding and stroking, but not by dexamethasone. Journal of Neuroendocrinology. ,vol. 11, pp. 581- 588 ,(2001) , 10.1046/J.1365-2826.1999.00329.X
Ruthie E. Amir, Ignatia B. Van den Veyver, Mimi Wan, Charles Q. Tran, Uta Francke, Huda Y. Zoghbi, Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nature Genetics. ,vol. 23, pp. 185- 188 ,(1999) , 10.1038/13810
Chris Murgatroyd, Dietmar Spengler, Epigenetic programming of the HPA axis: Early life decides Stress. ,vol. 14, pp. 581- 589 ,(2011) , 10.3109/10253890.2011.602146
Jeffrey G. Tasker, James P. Herman, Mechanisms of rapid glucocorticoid feedback inhibition of the hypothalamic–pituitary–adrenal axis Stress. ,vol. 14, pp. 398- 406 ,(2011) , 10.3109/10253890.2011.586446
M S Oitzl, E R de Kloet, Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning. Behavioral Neuroscience. ,vol. 106, pp. 62- 71 ,(1992) , 10.1037//0735-7044.106.1.62
A. Vicentic, D. Francis, M. Moffett, A. Lakatos, G. Rogge, G.W. Hubert, J. Harley, M.J. Kuhar, Maternal separation alters serotonergic transporter densities and serotonergic 1A receptors in rat brain. Neuroscience. ,vol. 140, pp. 355- 365 ,(2006) , 10.1016/J.NEUROSCIENCE.2006.02.008