The response of circulating levels of the interleukin-6/interleukin-6 receptor complex to exercise in young men.
作者： S.R. Gray , M. Clifford , R. Lancaster , M. Leggate , M. Davies
DOI: 10.1016/J.CYTO.2009.05.011
关键词: Receptor 、 Endocrinology 、 Plasma volume 、 Lactate threshold 、 Hematocrit 、 Internal medicine 、 Interleukin-6 receptor 、 Interleukin 6 、 Hemoglobin 、 Venous blood 、 Medicine
摘要: The formation of an interleukin-6/IL-6 receptor (IL-6/IL-6R) complex increases the biological activity and half-life IL-6, with its response to exercise currently unknown. aim present study was determine circulating levels IL-6/IL-6R exercise. Nine healthy male participants performed 1 h cycling at a workload required elicit 90% lactate threshold. Venous blood samples were taken rest, immediately post-exercise after 1.5 rest. Hemoglobin concentration hematocrit measured estimate changes in plasma volume during concentrations sIL-6R via ELISA corrected for volume. A single bout acute resulted 5-fold increase (P < 0.05) IL-6 1.2-fold These returned baseline cessation There 2.1-fold remaining 1.8 times elevated has demonstrated, first time, that are increased young males.
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sci-hub.se 参考文章(50)
Stefan Rose-John, Coordination of interleukin-6 biology by membrane bound and soluble receptors. Advances in Experimental Medicine and Biology. ,vol. 495, pp. 145- 151 ,(2001) , 10.1007/978-1-4615-0685-0_19
G. Discolo, R.L. Moritz, L.D. Ward, R.J. Simpson, A. Hammacher, G.J. Howlett, K. Yasukawa, High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130. Journal of Biological Chemistry. ,vol. 269, pp. 23286- 23289 ,(1994) , 10.1016/S0021-9258(17)31651-4
M Honda, H Suzuki, T Tokunaga, T Kishimoto, K Yasukawa, T Saito, Y Osugi, M Cheng, S Yamamoto, Human soluble IL-6 receptor: its detection and enhanced release by HIV infection. Journal of Immunology. ,vol. 148, pp. 2175- 2180 ,(1992)
Thomas Jostock, Jürgen Müllberg, Suat Özbek, Raja Atreya, Guido Blinn, Nicole Voltz, Martina Fischer, Markus F. Neurath, Stefan Rose-John, Soluble gp130 is the natural inhibitor of soluble interleukin‐6 receptor transsignaling responses FEBS Journal. ,vol. 268, pp. 160- 167 ,(2001) , 10.1046/J.1432-1327.2001.01867.X
T Kishimoto, S Akira, M Narazaki, T Taga, Interleukin-6 family of cytokines and gp130. Blood. ,vol. 86, pp. 1243- 1254 ,(1995) , 10.1182/BLOOD.V86.4.1243.BLOODJOURNAL8641243
S Rose-John, P C Heinrich, Soluble receptors for cytokines and growth factors: generation and biological function Biochemical Journal. ,vol. 300, pp. 281- 290 ,(1994) , 10.1042/BJ3000281
Shizuo Akira, Tetsuya Taga, Tadamitsu Kishimoto, Interleukin-6 in biology and medicine Advances in Immunology. ,vol. 54, pp. 1- 78 ,(1993) , 10.1016/S0065-2776(08)60532-5
Mari A. Nowell, Peter J. Richards, Sankichi Horiuchi, Naoki Yamamoto, Stefan Rose-John, Nicholas Topley, Anwen S. Williams, Simon A. Jones, Soluble IL-6 Receptor Governs IL-6 Activity in Experimental Arthritis: Blockade of Arthritis Severity by Soluble Glycoprotein 130 Journal of Immunology. ,vol. 171, pp. 3202- 3209 ,(2003) , 10.4049/JIMMUNOL.171.6.3202
Simon A. Jones, Directing transition from innate to acquired immunity: defining a role for IL-6. Journal of Immunology. ,vol. 175, pp. 3463- 3468 ,(2005) , 10.4049/JIMMUNOL.175.6.3463
M Murakami, M Hibi, N Nakagawa, T Nakagawa, K Yasukawa, K Yamanishi, T Taga, T Kishimoto, IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase Science. ,vol. 260, pp. 1808- 1810 ,(1993) , 10.1126/SCIENCE.8511589