The response of interleukin-6 and soluble interleukin-6 receptor isoforms following intermittent high intensity and continuous moderate intensity cycling.

摘要: As interleukin-6 (IL-6), its soluble receptor (sIL-6R), and the IL-6/sIL-6R complex is transiently elevated in response to prolonged moderate-intensity exercise, this study investigated how these levels would be modulated by an acute bout of high-intensity intermittent (HIIT) exercise comparison continuous (MOD). This also expression differentially spliced sIL-6R (DS-sIL-6R) exercise. Eleven healthy males completed two trials matched for external work done (582 ± 82 kJ). During MOD, participants cycled at 61.8 (2.6)% VO(2peak) 58.7 (1.9) min, while HIIT consisted ten 4-min intervals cycling 87.5 (3.4)% [Formula: see text] separated 2-min rest. Blood samples were collected pre-exercise, post-exercise, 1.5, 6, 23 h post-exercise. Plasma IL-6, sIL-6R, complex, DS-sIL-6R measured enzyme-linked immunosorbent assay. caused a significantly greater increase IL-6 than MOD (P = 0.018). Both resulted (P < 0.001), however, was not different between trials. Soluble IL-6R peaked 6 post-exercise both increased with (P = 0.02), representing 0.49% total increase. investigation has demonstrated that after comparable exercise; nor MOD. The current shown first time derived from proteolytic cleavage differential splicing.