Metabolically Healthy Obesity.

摘要: Obesity contributes to reduced life expectancy, impaired quality of life, and disabilities, mainly in those individuals who develop cardiovascular diseases, type 2 diabetes, osteoarthritis, cancer. However, there is a large variation the individual risk developing obesity-associated comorbid diseases that cannot simply be explained by extent adiposity. Observations proportion with obesity have significantly lower for cardiometabolic abnormalities led concept metabolically healthy (MHO). Although no clear definition, normal glucose lipid metabolism parameters-in addition absence hypertension-usually serve as criteria diagnose MHO. Biological mechanisms underlying MHO amounts ectopic fat (visceral liver), higher leg deposition, expandability subcutaneous adipose tissue, preserved insulin sensitivity, beta-cell function well better cardiorespiratory fitness compared unhealthy obesity. Whereas metabolic may reduce diabetes obesity, it still comparison lean individuals. In addition, seems transient phenotype further justifying therapeutic weight loss attempts-even this subgroup-which might not benefit from reducing body same patients Metabolically represents model study linking complications. should considered safe condition, which does require treatment, but guide decision-making personalized risk-stratified treatment.