HIFU-induced cavitation and heating in ex vivo porcine subcutaneous fat.

摘要: The present study is motivated by the fact that there are no published studies quantifying cavitation activity and heating induced ultrasound in adipose tissue currently reliable techniques for monitoring successful deposition of energy fat real time. High-intensity focused (HIFU) exposures were performed excised porcine at four different frequencies (0.5, 1.1, 1.6 3.4 MHz) over a range pressure amplitudes exposure durations. transmission losses arising from reflection skin interface attenuation through quantified all using an embedded needle hydrophone. A 15 MHz passive detector (PCD) coaxial to HIFU transducer was used capture acoustic emissions emanating focus during exposures, while focal temperature rise measured minimally invasive thermocouples. Repeatable rises excess 10°C could be readily instigated across intensities (Ispta) 50 W/cm(2) within first 2 s exposure. Even though not initiated situ peak rarefactional (p(-)) 0-3 MPa explored study, inertial always 0.5 pressures greater than found enhance heat deposition. good correlation identified between broadband detected PCD MHz, particularly short which exploited as tool noninvasive treatment delivery.