Quantitative assessment of reactive oxygen sonochemically generated by cavitation bubbles

摘要: Acoustic cavitation bubbles can induce not only a thermal bioeffect but also chemical bioeffect. When collapse and oscillate violently, they produce reactive oxygen species (ROS) that cause irreversible changes to the tissue. A sonosensitizer promote such ROS generation. treatment method using is called sonodynamic treatment. Rose bengal (RB) one of sonosensitizers whose in vivo vitro studies have been reported. In treatment, it important at high efficiency. For efficient generation ROS, triggered high-intensity focused ultrasound (HIFU) sequence has proposed. this study, were generated chamber where RB solution was sealed, high-speed camera captured behavior these bubbles. The amount quantified by potassium iodide (KI) compared with pictures investigate effectiveness HIFU sequence. As result, could be obtained efficiently