Invited Review: Functional genomics in the mouse: powerful techniques for unraveling the basis of human development and disease
DOI: 10.1152/JAPPLPHYSIOL.00209.2003
关键词: DNA sequencing 、 Functional genomics 、 Computational biology 、 Gene 、 Biology 、 Genetics 、 Chromosome engineering 、 Model organism 、 Human genome 、 Genomics 、 Genome
摘要: Now that near-complete DNA sequences of both the mouse and human genomes are available, next major challenge will be to determine how each these genes functions, alone in combination with other genome. The has a long rich history biological research, many consider it model organism for study development disease. Over past few years, exciting progress been made developing techniques chromosome engineering, mutagenesis, mapping maintenance mutations, identification mutant mouse. In this mini-review, powerful presented along their application development, physiology,
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