Apparatuses and methods for the production of haematophagous organisms and parasites suitable for vaccine production

作者: Stephen L. Hoffman , Thomas C. Luke

DOI:

关键词: Parasitic life cyclesBiologyMicrobiologyAnophelesVaccine ProductionParasite hostingPlasmodium speciesHost (biology)

摘要: Disclosed are apparatuses and methods for the production of parasites in haematophagous insects generally, Plasmodium species sporozoites Anopheles mosquitoes, specifically; strains with desired properties such as hypoallergenicity or hyperinfectivity; producing a parasite strain that is capable withstanding cyropreservation at temperatures close to freezing; injection an attenuated vaccine; free from contamination by unwanted biological agents; reconstruction complex parasitic life cycles aseptically avoid insect vector host agents.

参考文章(32)
S. Hurtado, M. L. Salas, J. F. Romero, J.C. Zapata, H. Ortiz, M. Arevalo-Herrera, S. Herrera, Regular production of infective sporozoites of Plasmodium falciparum and P. vivax in laboratory-bred Anopheles albimanus Annals of Tropical Medicine and Parasitology. ,vol. 91, pp. 49- 60 ,(1997) , 10.1080/00034983.1997.11813111
Stefan H. I. Kappe, Kai-Uwe C. Matuschewski, Ann-Kristin Mueller, Live genetically attenuated malaria vaccine ,(2004)
Nelly Camargo, Victor Nussenzweig, Agam P. Singh, Karine Kaiser, Stefan H. I. Kappe, Plasmodium axenic liver stages as a noninfectious whole organism malaria vaccine ,(2004)
Susan E. Wade, Jay R. Georgi, Artificial system and method for breeding fleas ,(1987)
D. R. Barnard, R. A. Ward, E. J. Gerberg, Manual for mosquito rearing and experimental techniques. Manual for mosquito rearing and experimental techniques.. pp. 98- ,(1994)
Brian C. Zeichner, Michael J. Perich, Lethal mosquito breeding container ,(2000)
Hilary Hurd, Ebtesam Al-Olayan, Geoffrey A. Butcher, In vitro methods for culturing vertebrate and mosquito stages of Plasmodium. Microbes and Infection. ,vol. 5, pp. 321- 327 ,(2003) , 10.1016/S1286-4579(03)00034-0
William Trager, James B. Jensen, Continuous culture of Plasmodium falciparum: its impact on malaria research International Journal for Parasitology. ,vol. 27, pp. 989- 1006 ,(1997) , 10.1016/S0020-7519(97)00080-5
DAVID F. CLYDE, HARRY MOST, VINCENT C. McCARTHY, JEROME P. VANDERBERG, Immunization of man against sporozite-induced falciparum malaria. The American Journal of the Medical Sciences. ,vol. 266, pp. 169- 177 ,(1973) , 10.1097/00000441-197309000-00002
Dale R. Hamilton, Richard E. Bradley, An integrated system for the production of gnotobiotic Anopheles quadrimaculatus Journal of Invertebrate Pathology. ,vol. 30, pp. 318- 324 ,(1977) , 10.1016/0022-2011(77)90140-9