The role of active DNA demethylation and Tet enzyme function in memory formation and cocaine action.

摘要: Active DNA modification is a major epigenetic mechanism that regulates gene expression in an experience-dependent manner, which thought to establish stable changes neuronal function and behavior. Recent discoveries regarding the Ten eleven translocation (Tet1-3) family of hydroxylases have provided new avenue for study active demethylation, may thus help advance our understanding how dynamic modifications lead long-lasting brain regions underlying learning memory, as well drug-seeking propensity relapse following abstinence. Drug addiction complex, relapsing disorder compulsive behavior can persist despite aversive consequences. Therefore, molecular mechanisms underlie onset persistence drug addiction, pronounced observed addicts, necessary development selective treatments therapies. In this mini-review, we provide overview involvement demethylation with emphasis on Tet enzymes 5-hydroxymethylcytosine (5-hmC) Memory share overlapping molecular, cellular, circuit functions allowing research one area inform other. Current discrepancies directions future studies focusing interplay between methylation they orchestrate required plasticity memory formation, are discussed.