Delirium in patients with acute ischemic stroke admitted to the non-intensive stroke unit: Incidence and association between clinical features and inflammatory markers.

摘要: Abstract Background Stroke patients with development of delirium have unfavorable outcomes, higher mortality, longer hospitalizations, and a greater degree dependence after discharge. Studies suggest that is associated abnormal immunological responses resultant increase in inflammatory markers. Objective Our aim was to determine whether there an entity relationship between delirium, inflammation acute ischemic stroke (AIS). Methods Sixty AIS admitted the hospital were consecutively recruited. Delirium diagnosed clinical assessment according Statistical Manual Mental Disorders, Fifth Edition (DSM-V) criteria. Enzyme-linked immunosorbent assay (ELISA) used measure serum levels Interleukin-1 beta (IL-1 beta), Interleukin 18 (IL-18), Tumor Necrosis Factor-alpha (TNF-alpha), Brain-Derived Neurotrophic Factor (BDNF), Neuron Specific Enolase (NSE) at admission. Results Eleven (18.3%) 60 majority ( n  = 8, 72.7%) hypoactive type. Delirious non-delirious had similar demographic features. significantly lengths stay, National Institutes Health Scale (NIHSS) admission discharge compared patients. In addition, no significant statistical difference delirious respect TNF-alpha, IL-1 beta, IL-18, BDNF NSE. This study suggests not scarce non-intensive unit, developing seems be NSE but length stay severity.