Neurobiology of schizophrenia.

摘要: With its hallucinations, delusions, thought disorder, and cognitive deficits, schizophrenia affects the most basic human processes of perception, emotion, judgment. Evidence increasingly suggests that is a subtle disorder brain development plasticity. Genetic studies are beginning to identify proteins candidate genetic risk factors for schizophrenia, including dysbindin, neuregulin 1, DAOA, COMT, DISC1, neurobiological normal variant forms these genes now well justified. We suggest DISC1 may offer especially valuable insights. Mechanistic properties their protein products should clarify molecular, cellular, systems-level pathogenesis schizophrenia. This can help redefine phenotype shed light on relationship between other major psychiatric disorders. Understanding pathologic yield novel targets more effective treatments.