Upregulation of relaxin receptors in the PDL by biophysical force.
作者： S. Y. Yang , J. W. Kim , S. Y. Lee , J. H. Kang , U. Ulziisaikhan
DOI: 10.1007/S00784-014-1276-4
关键词: Receptor 、 Downregulation and upregulation 、 Immunology 、 Messenger RNA 、 In vitro 、 Matrix metalloproteinase 、 Periodontal fiber 、 Vascular endothelial growth factor 、 Cell biology 、 Relaxin 、 Chemistry
摘要: We have previously reported that relaxin (Rln) expression from the ovary is upregulated by orthodontic tooth movement. This study was performed to test hypothesis Rln family peptides (Rxfps), G-protein-coupled receptor, induced in periodontal ligament (PDL) cells modulate molecules involved tissue remodeling while applying biophysical force. Rats were implanted with appliances investigate changes Rxfps vivo. An vitro force analysis measure level of Rxfp 1 messenger RNA (mRNA) primary human PDL cells. The levels 2 transcription and translation increased a time-dependent manner during localized immunofluorescence. In analyses revealed mRNA significantly both compression tension matrix metalloproteinase (MMP)-1, MMP-2, interleukin-6, vascular endothelial growth factor mRNA, which are important for remodeling, also changed under application treatment. responded effector upregulating may serve as turnover molecule complex control
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