Prostaglandin E1 reduces ischemia/reperfusion injury by normalizing nitric oxide and superoxide release.

作者: Igor Huk , Viktor Brovkovych , Joseph Nanobashvili , Christoph Neumayer , Peter Polterauer

DOI: 10.1097/00024382-200014020-00026

关键词: IschemiaPeroxynitriteAnesthesiaProstaglandin E1SuperoxideNitric oxidePharmacologyReperfusion injuryVasoconstrictionCalcium fluxChemistry

摘要: ABSTRACT—To test the effects of prostaglandin E1 on 2.5 h ischemia followed by 2 reperfusion, continuous nitric oxide measurements (electrochemical) were correlated with intermittent assays superoxide and peroxynitrite levels (chemiluminescence) ischemia/reperfusion injury in rabbit a

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