Anthrax toxin: the long and winding road that leads to the kill
作者： Laurence Abrami , Nuria Reig , F. Gisou van der Goot
DOI: 10.1016/J.TIM.2004.12.004
关键词: Biology 、 Microbiology 、 Virulence 、 Receptor 、 Anthrax toxin 、 Endocytic cycle 、 Enzyme 、 Toxin 、 Bacillus anthracis 、 Protein subunit
摘要: The past five years have led to a tremendous increase in our molecular understanding of the mode action anthrax toxin, one two main virulence factors produced by Bacillus anthracis . structures each three components toxin – lethal factor (LF), edema (EF) and protective antigen (PA) been solved not only their monomeric forms but, depending on subunit, heptameric form, bound substrate, co-factor or receptor. endocytic route followed has also unraveled enzymatic mechanisms EF LF elucidated.
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