Role of nerve growth factor in oxidant-antioxidant balance and neuronal injury. I. Stimulation of hydrogen peroxide resistance.
作者： G. R. Jackson , L. Apffel , K. Werrbach-Perez , J. R. Perez-Polo
关键词: Peripheral nervous system 、 Catalase 、 Neuroglia 、 Hydrogen peroxide 、 Cell biology 、 Programmed cell death 、 Internal medicine 、 Chemistry 、 Stimulation 、 Superoxide dismutase 、 Nerve growth factor 、 Endocrinology
摘要: The nerve growth factor protein (NGF) regulates neuronal cell death during the development of embryonic sensory and sympathetic neurons in peripheral nervous system (PNS). NGF protects rat pheochromocytoma line PC12, a useful model responsive neurons, from hydrogen peroxide, which interacts with ferrous iron to generate hydroxyl radicals. Exogenous catalase provides protection, whereas superoxide dismutase (SOD) has no effect on survival when PC12 cells are challenged peroxide. treatment increases activity catalase. protection peroxide is partially abolished by aminotriazole (Az), low molecular weight inhibitor. Taken together, these data consistent hypothesis that peroxidative events consequent via an induction free radical detoxifying mechanisms, such as activity.
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