The role of the epidermal growth factor receptor in the mechanism and treatment of colorectal cancer.

摘要: The epidermal growth factor receptor is a member of the tyrosine kinase family whose members play critical role in oncogenesis. In particular, EGFR has been shown to participate colon cancer development. Due its progression cancer, become an attractive target for therapy and two different classes biologic agents have evaluated: monoclonal antibodies inhibitors. These groups differ specific molecular site which they on their efficacy treatment cancer. This review will discuss EGFR's evolving as prognostic predictive biomarker Once thought be inherent anti-EGFR (MAbs) replaced by KRAS some extent BRAF. both MAbs, cetuximab panitumumab, clearly demonstrated depend upon mutational status. biomarkers taken another step closer towards goal tailored therapy.