Algorithm for Modification of Somatic Cancer Evolution

摘要: Most clinically distinguishable malignant tumors are characterized by specific mutations, patterns of chromosomal rearrangements and a predominant mechanism genetic instability. It has been suggested that the internal dynamics genomic modifications as opposed to external evolutionary forces have significant complex impact on Darwinian species evolution. A similar situation can be expected for somatic cancer evolution key mechanisms encountered in such duplications, or deletions genes also constitute prevalent mutation cancers with The invention is an algorithm which based systems concept describing putative constraints genome architecture allows identification therapeutic target individual patients do not represent oncogenes tumor suppressor but become targets due Target regulatory elements may identified their designation essential cells patient normal tissue they process phylogenetic trees constructed multilayered maps. used delivering personalized therapy well industrial novel anti-cancer drugs. designing software programs allow prediction natural history disease patients.