Functional Polymorphism of IL-1 Alpha and Its Potential Role in Obesity in Humans and Mice
作者： Jae-Young Um , Hong-Kun Rim , Su-Jin Kim , Hye-Lin Kim , Seung-Heon Hong
DOI: 10.1371/JOURNAL.PONE.0029524
关键词: Body mass index 、 Genotype 、 Immunology 、 Obesity 、 Triglyceride 、 Cellular differentiation 、 Adipose tissue 、 In vivo 、 Biology 、 Proinflammatory cytokine 、 General Biochemistry, Genetics and Molecular Biology 、 General Agricultural and Biological Sciences 、 General Medicine
摘要: Proinflammatory cytokines secreted from adipose tissue contribute to the morbidity associated with obesity. IL-1α is one of proinflammatory cytokines; however, it has not been clarified whether may also cause In this study, we investigated polymorphisms in human A total 260 obese subjects were genotyped for C-889T (rs1800587) and G+4845T (rs17561). Analyses genotype distributions revealed that both (rs17561) an increase body mass index healthy women. addition, effect rs1800587 on transcriptional activity was explored pre-adipocyte 3T3-L1 cells. Significant difference found between polymorphism regulatory region gene activity. We extended these observations vivo a high-fat diet-induced mouse model vitro levels dramatically augmented mice, triglyceride increased 12 hours after injection. Taken together, treatment regulated differentiation preadipocytes. functional have critical function development
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Charles B. Foster, Thomas Lehrnbecher, Susan Samuels, Steven Stein, Femke Mol, Julie A. Metcalf, Kathleen Wyvill, Seth M. Steinberg, Joseph Kovacs, Andrew Blauvelt, Robert Yarchoan, Stephen J. Chanock, An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus Blood. ,vol. 96, pp. 2562- 2567 ,(2000) , 10.1182/BLOOD.V96.7.2562
Jean-Philippe Bastard, Claude Jardel, Jacques Delattre, Bernard Hainque, Eric Bruckert, Flavien Oberlin, Evidence for a link between adipose tissue interleukin-6 content and serum C-reactive protein concentrations in obese subjects. Circulation. ,vol. 99, pp. 2221- 2222 ,(1999) , 10.1161/CIRC.99.16.2219/C
Charles A. Dinarello, Raffaella Faggioni, Jean D. Sipe, Pietro Ghezzi, Hui Zheng, Alan R. Shaw, Giamila Fantuzzi, Fabio Benigni, Effect of endotoxin in IL-1 beta-deficient mice. Journal of Immunology. ,vol. 157, pp. 291- 296 ,(1996)
Tomáš Mráček, Barbara Cannon, Josef Houštěk, IL-1 and LPS but not IL-6 inhibit differentiation and downregulate PPAR gamma in brown adipocytes Cytokine. ,vol. 26, pp. 9- 15 ,(2004) , 10.1016/J.CYTO.2003.12.001
Chumpon Wilasrusmee, Monica Da Silva, Bhupinder Singh, Smita Kittur, Josephine Siddiqui, David Bruch, Skuntala Wilasrusmee, Dilip S. Kittur, A New in Vitro Model to Study Endothelial Injury Journal of Surgical Research. ,vol. 104, pp. 131- 136 ,(2002) , 10.1006/JSRE.2002.6429
Helen N Sweeting, Measurement and Definitions of Obesity In Childhood and Adolescence: A field guide for the uninitiated Nutrition Journal. ,vol. 6, pp. 32- 32 ,(2007) , 10.1186/1475-2891-6-32
I. Rainero, M. Bo, M. Ferrero, W. Valfrè, G. Vaula, L. Pinessi, Association between the interleukin-1α gene and Alzheimer’s disease: a meta-analysis Neurobiology of Aging. ,vol. 25, pp. 1293- 1298 ,(2004) , 10.1016/J.NEUROBIOLAGING.2004.02.011
Martin Braddock, Anthony Quinn, Targeting IL-1 in inflammatory disease: new opportunities for therapeutic intervention Nature Reviews Drug Discovery. ,vol. 3, pp. 330- 339 ,(2004) , 10.1038/NRD1342
F.L Sciacca, C Ferri, F Licastro, F Veglia, I Biunno, A Gavazzi, E Calabrese, F Martinelli Boneschi, S Sorbi, C Mariani, M Franceschi, L.M.E Grimaldi, Interleukin-1B polymorphism is associated with age at onset of Alzheimer's disease. Neurobiology of Aging. ,vol. 24, pp. 927- 931 ,(2003) , 10.1016/S0197-4580(03)00011-3
Xing Wei, Xianming Chen, Christine Fontanilla, Liming Zhao, Zhong Liang, Richard Dodel, Hampel Hampel, Martin Farlow, Yansheng Du, C/T conversion alters interleukin-1A promoter function in a human astrocyte cell line Life Sciences. ,vol. 80, pp. 1152- 1156 ,(2007) , 10.1016/J.LFS.2006.12.011