IL-37 protects against obesity-induced inflammation and insulin resistance

摘要: Cytokines of the IL-1 family are important modulators obesity-induced inflammation and development systemic insulin resistance. Here we show that member IL-37, recently characterized as an anti-inflammatory cytokine, ameliorates Mice transgenic for human IL-37 (IL-37tg) exhibit reduced numbers adipose tissue macrophages, increased circulating levels adiponectin preserved glucose tolerance sensitivity after 16 weeks HFD. In vitro treatment adipocytes with recombinant reduces adipogenesis activates AMPK signalling. humans, elevated steady-state mRNA positively correlated a lower inflammatory status tissue. These findings reveal modulator during resistance in both mice suggest is potential target type 2 diabetes.