Human Tumor-Infiltrating Myeloid Cells: Phenotypic and Functional Diversity.

摘要: Our current understanding of human tumor-resident myeloid cells is, for the most part, based on a large body work in murine models or studies enumerating patient tumor samples using immunohistochemistry (IHC). This has led to establishment theory that, by and large, are either "protumor" M2 macrophages myeloid-derived suppressor (MDSC). concept accelerated our progression enabled elucidation many key regulatory mechanisms involved cell recruitment, polarization, activation. On other hand, this paradigm does not embrace complexity phenotype (IHC can only measure 1 2 markers per sample) their possible divergent function hostile microenvironment. Here, we examine criteria that define tumor-infiltrating subsets provide comprehensive critical review nomenclature cancer. We also highlight new evidence characterizing contribution cancer pathogenesis derived from clinical drawing comparisons with where necessary. then which regulated tumors humans how these being targeted therapeutically.