Chemopreventive potential of genistein and daidzein in combination during 7,12-dimethylbenz[a]anthracene (DMBA) induced mammary carcinogenesis in Sprague-Dawley rats.
作者： P. Pugalendhi , S. Manoharan
DOI: 10.3923/PJBS.2010.279.286
关键词: Mammary gland 、 Daidzein 、 Biochanin A 、 DMBA 、 7,12-Dimethylbenz[a]anthracene 、 Genistein 、 Subcutaneous injection 、 Pharmacology 、 Chemistry 、 Oral administration
摘要: The chemopreventive potential of two major soy isoflavones, genistein and daidzein, in mammary carcinogenesis remains enigmatic. aim the present study was to investigate orally administered genistein, daidzein genistein+daidzein 7,12-dimethylbenz[a]anthracene (DMBA) induced Sprague-Dawley rats. assessed by monitoring tumor incidence volume as well analyzing status biochemical markers (17beta-estradiol (E2)), enzymatic non-enzymatic antioxidants phase I II detoxification enzymes) during DMBA-induced carcinogenesis. A single subcutaneous injection DMBA (25 mg rat(-1)) gland developed carcinoma female Oral administration (20 kg(-1) b.wt.), b.wt.) mg+20 treated rats significantly prevented brought back above said variables. Genistein combination have shown pronounced than either or alone. revealed is probably due their antilipid peroxidative efficacy modulatory effect on cascade
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