Negative Feedback Regulation of IFN-γ Pathway by IFN Regulatory Factor 2 in Esophageal Cancers

摘要: IFN-γ is an antitumor cytokine that inhibits cell proliferation and induces apoptosis after engagement with the receptors (IFNGR) expressed on target cells, whereas IFN regulatory factor 2 (IRF-2) able to block effects of by repressing transcription IFN-γ–induced genes. Thus far, few studies have explored influences human esophageal cancer cells. In present study, therefore, we investigated in detail functions The results clinical samples cancers showed level was increased tumor tissues positively correlated progression IRF-2 expression, IFNGR1 decreased negatively expression. Consistently, vitro experiments low concentration induced expression potential promotion growth, moreover, suppress cells binding a specific motif promoter, which lowered sensitivity IFN-γ. Taken together, our disclosed new IRF-2–mediated inhibitory mechanism for pathway cells: up-regulation, then up-regulated endogenous level, finally, loss turned enhance resistance Accordingly, implied might act as mediator cancers. [Cancer Res 2008;68(4):1136–43]