Tissue-based miRNA mapping in alcoholic liver cirrhosis: different profiles in cirrhosis with or without hepatocellular carcinoma.
作者： Philipp Felgendreff , Nathanael Raschzok , Kerstin Kunze , Annekatrin Leder , Steffen Lippert
DOI: 10.1080/1354750X.2019.1691267
关键词: Context (language use) 、 Biomarker (medicine) 、 Gastroenterology 、 Hepatocellular carcinoma 、 Alcoholic liver disease 、 Microarray analysis techniques 、 Internal medicine 、 Microarray 、 Liver transplantation 、 Cirrhosis 、 Medicine
摘要: Context: Alcoholic liver cirrhosis is a significant risk factor for the development of hepatocellular carcinoma (HCC). The importance tumour-associated in or progression HCC not understood. MiRNAs are important regulators development, but their role due to alcoholic unclear.Objective: aim this study detection miRNA expression cirrhosis, and HCC.Materials methods: We analysed differences profiles HCC, without samples from 30 patients who underwent transplantation because disease.Results: Microarray analyses revealed 40 significantly differentially expressed miRNAs between tissue tissue. Furthermore, microarray analysis discovered 56 HCC.Discussion: profile with could improve understanding as well lead new diagnostic tool screening.Conclusion: were able show first time, promising biomarker context disease.
sci-hub.se 参考文章(50)
Raafat A El-Awady, Fatema Hersi, Hala Al-Tunaiji, Ekram M Saleh, Abdel-Hady A Abdel-Wahab, Amer Al Homssi, Mousa Suhail, Ahmed El-Serafi, Taleb Al-Tel, Epigenetics and miRNA as predictive markers and targets for lung cancer chemotherapy Cancer Biology & Therapy. ,vol. 16, pp. 1056- 1070 ,(2015) , 10.1080/15384047.2015.1046023
Xiaodong Lu, Jia Lu, The significance of detection of serum miR-423-5p and miR-484 for diagnosis of colorectal cancer. Clinical Laboratory. ,vol. 61, pp. 187- 190 ,(2015) , 10.7754/CLIN.LAB.2014.140625
Jing-Jun Yan, Yu-Nan Zhang, Jia-Zhi Liao, Kun-peng Ke, Ying Chang, Pei-Yuan Li, Min Wang, Ju-Sheng Lin, Xing-Xing He, MiR-497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG-1. Oncotarget. ,vol. 6, pp. 29527- 29542 ,(2015) , 10.18632/ONCOTARGET.5012
Jin Wang, Ke-Yong Zhang, Song-Mei Liu, Subrata Sen, Tumor-Associated Circulating MicroRNAs as Biomarkers of Cancer Molecules. ,vol. 19, pp. 1912- 1938 ,(2014) , 10.3390/MOLECULES19021912
Sven Jonas, Wolf O Bechstein, Thomas Steinmüller, Martin Herrmann, Cornelia Radke, Thomas Berg, Utz Settmacher, Peter Neuhaus, Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis Hepatology. ,vol. 33, pp. 1080- 1086 ,(2001) , 10.1053/JHEP.2001.23561
JIN MA, RUI GUO, TING WANG, XIA PAN, XIAOYONG LEI, Let‑7b binding site polymorphism in the B‑cell lymphoma‑extra large 3'UTR is associated with fluorouracil resistance of hepatocellular carcinoma Molecular Medicine Reports. ,vol. 11, pp. 677- 681 ,(2015) , 10.3892/MMR.2014.2692
Linhui Liang, Chun-Ming Wong, Qiao Ying, Dorothy Ngo-Yin Fan, Shenglin Huang, Jie Ding, Jian Yao, Mingxia Yan, Jinjun Li, Ming Yao, Irene Oi-Lin Ng, Xianghuo He, MicroRNA‐125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2 Hepatology. ,vol. 52, pp. 1731- 1740 ,(2010) , 10.1002/HEP.23904
Carlos Rodríguez de Lope, Silvia Tremosini, Alejandro Forner, María Reig, Jordi Bruix, Management of HCC Journal of Hepatology. ,vol. 56, ,(2012) , 10.1016/S0168-8278(12)60009-9
Francis Y Yao, Linda Ferrell, Nathan M Bass, Jessica J Watson, Peter Bacchetti, Alan Venook, Nancy L Ascher, John P Roberts, Liver transplantation for hepatocellular carcinoma: Expansion of the tumor size limits does not adversely impact survival Hepatology. ,vol. 33, pp. 1394- 1403 ,(2001) , 10.1053/JHEP.2001.24563
Enrico Munari, Luigi Marchionni, Apurva Chitre, Masamichi Hayashi, Guido Martignoni, Matteo Brunelli, Stefano Gobbo, Pedram Argani, Mohamad Allaf, Mohammad O. Hoque, George J. Netto, Clear cell papillary renal cell carcinoma: micro-RNA expression profiling and comparison with clear cell renal cell carcinoma and papillary renal cell carcinoma. Human Pathology. ,vol. 45, pp. 1130- 1138 ,(2014) , 10.1016/J.HUMPATH.2014.01.013