The significance of detection of serum miR-423-5p and miR-484 for diagnosis of colorectal cancer.

摘要: Background Colorectal cancer (CRC) is a severe disease with considerable morbidity and mortality. Stable presence of miRNAs in serum enables them to be biomarkers for early diagnosis surveillance the progress CRC. Methods The blood samples 53 CRC patients I-IV stage pre therapy 50 controlled healthy people were collected total RNA was extracted. level miR-423-5p miR-484 detected by qPCR. Results In I-II CRC, significantly elevated compared control, whereas attenuated. III-IV, no significance difference found between increased dramatically. Conclusions study provides possibility that detection miR-484-5p may useful method