MicroRNA‑423‑5p inhibits colon cancer growth by promoting caspase‑dependent apoptosis
作者： Wenzhuo Jia , Tao Yu , Qi An , Xianglong Cao , Hongda Pan
关键词:
摘要: Plasma microRNA (miR)-423-5p is a potential biomarker for the detection of colon cancer. However, expression and biological role miR-423-5p in tumorigenesis remains unclear. In current study, reverse transcription-quantitative polymerase chain reaction was used to determine malignant tissues plasma from patients with Cell viability, colony formation apoptosis assays, as well western blotting, were performed investigate regulatory mechanisms The results demonstrated that downregulated tumor cancer, cancer cell lines. Furthermore, overexpression promoted resulted inhibition proliferation formation. Mechanistically, induced caspases 3, 8 9, p53 effect z-VAD treatment indicated miR-423-5p-mediated caspase-dependent. These suggest suppressor diagnostic target enable early
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