LncRNA LINC00319 accelerates ovarian cancer progression through miR-423-5p/NACC1 pathway.
作者： Wenling Du , Zejiao Feng , Qinqin Sun
DOI: 10.1016/J.BBRC.2018.11.006
关键词:
摘要: Long noncoding RNA (lncRNA) LINC00319 has been reported to promote carcinogenesis of lung cancer and cutaneous squamous cell carcinoma. However, the role mechanism in ovarian progression is unclear. In this study, expression was found be upregulated tissues lines. And our evidence showed that could a potential prognostic biomarker for patients with cancer. Cell Counting Kit-8 (CCK-8), colony formation transwell assays indicated upregulation promoted proliferation, migration invasion cells. Bioinformatics analysis luciferase reporter assay revealed worked as sponge miR-423-5p. Furthermore, miR-423-5p directly targeted NACC1. qRT-PCR western blot results demonstrated upregulates NACC1 through inhibiting Moreover, we observed an inverse correlation between or tissues. Finally, rescue restoration rescued potentials LINC00319-depleted conclusion, findings promotes upregulating by restraining
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