lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal

作者: Pingping Zhu , Yanying Wang , Guanling Huang , Buqing Ye , Benyu Liu

DOI: 10.1038/NSMB.3235

关键词: Regulation of gene expressionBeta-cateninCell biologyBiologyCancer stem cellWnt signaling pathwayCateninMethyltransferaseMolecular biologyEZH2Methylation

摘要: Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence and heterogeneity of hepatocellular carcinoma (HCC); however, the molecular mechanisms underlying their …

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