CCAT1 promotes triple-negative breast cancer progression by suppressing miR-218/ZFX signaling.
作者： Chunyong Han , Xuebiao Li , Qian Fan , Guangshu Liu , Jian Yin
关键词:
摘要: Long non-coding RNAs (lncRNAs) regulate cancer development and progression. Here, we investigated the role of lncRNA CCAT1 in triple-negative breast (TNBC). expression was higher TNBC cells than normal epithelial cells. Additionally, patient tumor tissue adjacent tissue. Silencing inhibited cell proliferation, migration, invasion vitro, growth progression vivo. Bioinformatics analysis revealed that microRNA-218 (miR-218) is a potential target CCAT1. resulted an increase miR-218 invasion. reversed effects knockdown on invasion, suggesting promotes by downregulating expression. We identified zinc finger protein ZFX as putative downstream through bioinformatics analysis. lines Overexpression tumor-suppressive Our data indicate targeting miR-218/ZFX axis.
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