MYC upregulated LINC00319 promotes human acute myeloid leukemia (AML) cells growth through stabilizing SIRT6
作者： Yanni Zhang , Zongxuan Huang , Fen Sheng , Zhaoyang Yin
DOI: 10.1016/J.BBRC.2018.12.133
关键词:
摘要: Long non-coding RNAs (lncRNAs) have been identified by accumulating studies as critical regulator in tumorigenesis and tumor development human cancers, including acute myeloid leukemia (AML). This study investigated the function underlying mechanism of LINC00319 AML progression. Firstly, low expression level whole blood healthy individuals was obtained from UCSC, its upregulation detected patients well cell lines. Besides, prognostic significance revealed patients. Functionally, loss-of-function assays that silence restrained proliferation but stimulated apoptosis cells. Furthermore, demonstrated proportional to MYC samples transcriptionally regulated MYC. Mechanistically, we FUS a shared RNA binding protein (RBP) interacting with both SIRT6. And SIRT6 at post-transcriptional through FUS-dependent pathway. Last not least, overexpression rescued suppressive effect knockdown on cells growth. Overall, our findings unveiled contributed leukemogenesis via elevating expression, indicating possible molecular target for treatment.
sci-hub.se 参考文章(33)
Masahiro Sokabe, Haruo Okado, Shinsuke Ishigaki, Gen Sobue, Tsuyoshi Udagawa, Yusuke Fujioka, Motoki Tanaka, Daiyu Honda, Satoshi Yokoi, Yuichi Riku, Daisuke Ibi, Taku Nagai, Kiyofumi Yamada, Hirohisa Watanabe, Masahisa Katsuno, Toshifumi Inada, Kinji Ohno, FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization Nature Communications. ,vol. 6, pp. 7098- 7098 ,(2015) , 10.1038/NCOMMS8098
Carolina P. de Souza Melo, Catharina B. Campos, Juliana de Oliveira Rodrigues, Joaquim C. Aguirre-Neto, Ângelo Atalla, Mara A. D. Pianovski, Edna K. Carbone, Luciana B. Q. Lares, Hélio Moraes-Souza, Shirlei Octacílio-Silva, Fabiano S. M. Pais, Alessandro C. de Souza Ferreira, Juliana G. Assumpção, Long non‐coding RNAs: biomarkers for acute leukaemia subtypes British Journal of Haematology. ,vol. 173, pp. 318- 320 ,(2016) , 10.1111/BJH.13588
Pedro J. Batista, Howard Y. Chang, Long Noncoding RNAs: Cellular Address Codes in Development and Disease Cell. ,vol. 152, pp. 1298- 1307 ,(2013) , 10.1016/J.CELL.2013.02.012
Dalia Barsyte-Lovejoy, Suzanne K. Lau, Paul C. Boutros, Fereshteh Khosravi, Igor Jurisica, Irene L. Andrulis, Ming S. Tsao, Linda Z. Penn, The c-Myc Oncogene Directly Induces the H19 Noncoding RNA by Allele-Specific Binding to Potentiate Tumorigenesis Cancer Research. ,vol. 66, pp. 5330- 5337 ,(2006) , 10.1158/0008-5472.CAN-06-0037
T-p Xu, X-x Liu, R Xia, L Yin, R Kong, W-m Chen, M-d Huang, Y-q Shu, SP1-induced upregulation of the long noncoding RNA TINCR regulates cell proliferation and apoptosis by affecting KLF2 mRNA stability in gastric cancer Oncogene. ,vol. 34, pp. 5648- 5661 ,(2015) , 10.1038/ONC.2015.18
Mariangela Morlando, Monica Ballarino, Alessandro Fatica, Long Non-Coding RNAs: New Players in Hematopoiesis and Leukemia. Frontiers of Medicine in China. ,vol. 2, pp. 23- 23 ,(2015) , 10.3389/FMED.2015.00023
Feng Yang, Xuchao Xue, Luming Zheng, Jianwei Bi, Yuhong Zhou, Kangkang Zhi, Yan Gu, Guoen Fang, Long non‐coding RNA GHET1 promotes gastric carcinoma cell proliferation by increasing c‐Myc mRNA stability FEBS Journal. ,vol. 281, pp. 802- 813 ,(2014) , 10.1111/FEBS.12625
Chi V. Dang, MYC on the Path to Cancer Cell. ,vol. 149, pp. 22- 35 ,(2012) , 10.1016/J.CELL.2012.03.003
Ramiro Garzon, Stefano Volinia, Dimitrios Papaioannou, Deedra Nicolet, Jessica Kohlschmidt, Pearlly S. Yan, Krzysztof Mrózek, Donna Bucci, Andrew J. Carroll, Maria R. Baer, Meir Wetzler, Thomas H. Carter, Bayard L. Powell, Jonathan E. Kolitz, Joseph O. Moore, Ann-Kathrin Eisfeld, James S. Blachly, William Blum, Michael A. Caligiuri, Richard M. Stone, Guido Marcucci, Carlo M. Croce, John C. Byrd, Clara D. Bloomfield, Expression and prognostic impact of lncRNAs in acute myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 111, pp. 18679- 18684 ,(2014) , 10.1073/PNAS.1422050112
Alessandro Fatica, Noncoding RNAs in Acute Myeloid Leukemia: From Key Regulators to Clinical Players Scientifica. ,vol. 2012, pp. 925758- 925758 ,(2012) , 10.6064/2012/925758