Noncoding RNAs in Acute Myeloid Leukemia: From Key Regulators to Clinical Players
作者： Alessandro Fatica
DOI: 10.6064/2012/925758
关键词:
摘要: Recent analyses have shown that human cells transcribe almost their entire genomes, implying the existence of a huge mass ncRNAs. At present, microRNAs are most investigated regulative non-coding RNAs. Several studies demonstrated play crucial role in hematopoietic differentiation and hematological malignancies, including acute myeloid leukemia (AML). Aberrant expression has been associated with specific genetic abnormalities clinical outcome patients AML. In addition, since can function as either oncogenes or tumor suppressor genes, potential using these molecules therapeutic targets opens up new opportunities future AML therapy. The recent demonstration other regulatory ncRNAs, addition to microRNAs, involved cell diseases, suggests they may also biological relevance This paper will describe ncRNAs discuss expectations for use diagnosis, prognosis, therapy
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