LncRNA LINC01061 sponges miR-612 to regulate the oncogenic role of SEMA4D in cholangiocarcinoma.
作者： Aijun Yu , Luwen Zhao , Qingmin Kang , Kai Chen , Jian Li
DOI: 10.1016/J.BBRC.2019.03.125
关键词:
摘要: Cholangiocarcinoma (CCA) is the most usual malignancy of biliary tract, possessing a relatively low overall survival rate due to limited treatment options. Recently, long non-coding RNAs (lncRNAs) have been testified marked regulatory impacts on human cancers. The purpose this paper explore potent regulation mechanism LINC01061 involved in CCA. Firstly, it was observed that expression heightened CCA cell lines, whose knockdown suppressed proliferation, induced apoptosis and restrained migration. Besides, existing cytoplasm cells interacted with miR-612. Moreover, subsequent experiments affirmed regulated SEMA4D by acting as competing endogenous RNA (ceRNA) At last, rescue assays validated overexpression restored repression caused silence biological activities containing To sum up, our present exploration demonstrated sponges miR-612 so upregulate for progression CCA, suggesting an optional promising effective target therapy patients
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