The Genetics of Colorectal Cancer

摘要: Colon cancer is a common disease that can be sporadic, familial, or inherited. Recent advances have contributed to the understanding of molecular basis these various patterns colon cancer. Germline genetic mutations are inherited syndromes; an accumulation somatic in cell sporadic cancer; and, Ashkenazi Jewish persons, mutation was previously thought polymorphism may cause familial Mutations three different classes genes been described etiology: oncogenes, suppressor genes, and mismatch repair genes. Knowledge many specific responsible for carcinogenesis allows phenotypic manifestations observed forms testing disease. Although possible available, it only adjunct clinical management persons at risk patients with As result causes availability screening methods such as colonoscopy, should prevent vast majority our society. Practicing clinicians recognize cancer, understand its causes, able use endoscopic prevention.