Progression Model for Pancreatic Cancer

作者: Ralph H. Hruban , Scott E. Kern , Michael Goggins , Jennifer Parsons

DOI:

关键词: Pancreatic diseaseCancer researchTumor progressionInternal medicineColonic epitheliumPancreatic cancerPancreatic Intraepithelial NeoplasiaGastroenterologyPancreasAdenocarcinomaMedicineCarcinoma

摘要: … cancer. For example, in 1988, the only significant genetic alteration that had been identified in pancreatic cancer … understanding of pancreatic cancer,and pancreatic cancer is now one …

参考文章(53)
Ralph H. Hruban, Robb E. Wilentz, Scott E. Kern, Genetic progression in the pancreatic ducts. American Journal of Pathology. ,vol. 156, pp. 1821- 1825 ,(2000) , 10.1016/S0002-9440(10)65054-7
E. Fearon, Hamilton, B Vogelstein, Clonal analysis of human colorectal tumors Science. ,vol. 238, pp. 193- 197 ,(1987) , 10.1126/SCIENCE.2889267
D Sidransky, T Tokino, Hamilton, K. Kinzler, B Levin, P Frost, B Vogelstein, Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors. Science. ,vol. 256, pp. 102- 105 ,(1992) , 10.1126/SCIENCE.1566048
Bert Vogelstein, Kenneth W. Kinzler, The multistep nature of cancer. Trends in Genetics. ,vol. 9, pp. 138- 141 ,(1993) , 10.1016/0168-9525(93)90209-Z
John D Day, Joseph A Digiuseppe, Charles Yeo, Myla Lai-Goldman, Steven M Anderson, Steven N Goodman, Scott E Kern, Ralph H Hruban, Immunohistochemical evaluation of HER-2/neu expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasms☆ Human Pathology. ,vol. 27, pp. 119- 124 ,(1996) , 10.1016/S0046-8177(96)90364-0
Elisabeth Brockie, Aditi Anand, Jorge Albores-Saavedra, Progression of atypical ductal hyperplasia/carcinoma in situ of the pancreas to invasive adenocarcinoma Annals of Diagnostic Pathology. ,vol. 2, pp. 286- 292 ,(1998) , 10.1016/S1092-9134(98)80020-8
Kenneth W. Kinzler, Bert Vogelstein, Cancer-susceptibility genes. Gatekeepers and caretakers Nature. ,vol. 386, pp. 761- 763 ,(1997) , 10.1038/386761A0
Steven M. Powell, Nathan Zilz, Yasmin Beazer-Barclay, Tracy M. Bryan, Stanley R. Hamilton, Stephen N. Thibodeau, Bert Vogelstein, Kenneth W. Kinzler, APC mutations occur early during colorectal tumorigenesis. Nature. ,vol. 359, pp. 235- 237 ,(1992) , 10.1038/359235A0
Gloria H. Su, Ralph H. Hruban, Ravi K. Bansal, G. Steven Bova, David J. Tang, Manu C. Shekher, Anne Marie Westerman, Mark M. Entius, Michael Goggins, Charles J. Yeo, Scott E. Kern, Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. American Journal of Pathology. ,vol. 154, pp. 1835- 1840 ,(1999) , 10.1016/S0002-9440(10)65440-5