What Would You Do? Specialists’ Perspectives on Cancer Genetic Testing, Prophylactic Surgery, and Insurance Discrimination
作者： Ellen T. Matloff , Heather Shappell , Karina Brierley , Barbara A. Bernhardt , Wendy McKinnon
DOI: 10.1200/JCO.2000.18.12.2484
关键词:
摘要: PURPOSE: To examine what cancer genetics specialists predict they would do personally if were at 50% risk of carrying a mutation that predisposes to hereditary breast/ovarian (BRCA1/BRCA2) and nonpolyposis colon (HNPCC). METHODS: Questionnaire survey the membership National Society Genetic Counselors (NSGC) Special Interest Group (SIG) in Cancer. RESULTS: Of 296 active members NSGC Cancer-SIG surveyed, 163 (55%) responded. Eighty-five percent predicted had BRCA1/BRCA2 mutation, pursue genetic testing. If tested positive for age 35, 25% prophylactic bilateral mastectomies 68%, oophorectomy. Ninety-one respondents believe testing HNPCC, 17% elect colectomy; 54%, hysterectomy; 52%, oophorectomy mutation. The majority (68%)...
sci-hub.se 参考文章(52)
Tucker Ma, Struewing Jp, Ponder Ba, Watson P, Lynch Ht, Easton Df, Prophylactic oophorectomy in inherited breast/ovarian cancer families. Journal of The National Cancer Institute Monographs. pp. 33- 35 ,(1995)
Steven A. Narod, Gilbert M. Lenoir, David Goldgar, Patricia Tonin, Sylvie Mazoyer, Yin Y. Shugart, Henry T. Lynch, Nadine Puget, Olga M. Serova, Valérie Dubois, Mutations in BRCA1 and BRCA2 in breast cancer families: Are there more breast cancer-susceptibility genes? American Journal of Human Genetics. ,vol. 60, pp. 486- 495 ,(1997)
Ronald B. J. Glass, Kenneth N. Rosenbaum, Detection of eight BRCA1 mutations in 10 breast/ovarian cancer families, including 1 family with male breast cancer. American Journal of Human Genetics. ,vol. 57, pp. 1- 5 ,(1995) , 10.1002/AJMG.1320570102
T. Kurosaki, B. Noble, H. Anton-Culver, D. Gordon, L. S. Friedman, B. A. J. Ponder, G. Casey, S. A. Gayther, Mutation analysis of BRCA1 and BRCA2 in a male breast cancer population American Journal of Human Genetics. ,vol. 60, pp. 313- 319 ,(1997)
G Geller, B A Bernhardt, T Doksum, K J Helzlsouer, P Wilcox, N A Holtzman, Decision-making about breast cancer susceptibility testing: how similar are the attitudes of physicians, nurse practitioners, and at-risk women? Journal of Clinical Oncology. ,vol. 16, pp. 2868- 2876 ,(1998) , 10.1200/JCO.1998.16.8.2868
Bryan T. Maguire, Response to Mail Questionnaires by Health Professionals Journal of economic and social measurement. ,vol. 17, pp. 87- 99 ,(1991) , 10.3233/JEM-1991-17203
C Lerman, C Hughes, S J Lemon, D Main, C Snyder, C Durham, S Narod, H T Lynch, What you don't know can hurt you: adverse psychologic effects in members of BRCA1-linked and BRCA2-linked families who decline genetic testing. Journal of Clinical Oncology. ,vol. 16, pp. 1650- 1654 ,(1998) , 10.1200/JCO.1998.16.5.1650
C Lerman, M Daly, A Masny, A Balshem, Attitudes about genetic testing for breast-ovarian cancer susceptibility. Journal of Clinical Oncology. ,vol. 12, pp. 843- 850 ,(1994) , 10.1200/JCO.1994.12.4.843
M. Steven Piver, Mohannad F. Jishi, Yoshiaki Tsukada, Guillermina Nava, Primary peritoneal carcinoma after prophylactic oophorectomy in women with a family history of ovarian cancer. A report of the Gilda Radner Familial Ovarian Cancer Registry. Cancer. ,vol. 71, pp. 2751- 2755 ,(1993) , 10.1002/1097-0142(19930501)71:9<2751::AID-CNCR2820710911>3.0.CO;2-J
M.J. Blacconiere, W.A. Oleckno, Health-promoting behaviours in public health: testing the health promotion model. Journal of The Royal Society for The Promotion of Health. ,vol. 119, pp. 11- 16 ,(1999) , 10.1177/146642409911900103