Mutation analysis of BRCA1 and BRCA2 in a male breast cancer population

摘要: A population-based series of 54 male breast cancer cases from Southern California were analyzed for germ-line mutations in the inherited breast/ovarian genes, BRCA1 and BRCA2. Nine (17%) patients had a family history and/or ovarian at least one first-degree relative. further seven (13%) reported second-degree relative no relatives. No found. Two (4% total) found to carry novel truncating BRCA2 gene. Only two carrying mutation cancer, with case The remaining eight (89%) relatives remain unaccounted by either gene or