ONCOGENESIS: Landscaping the Cancer Terrain
作者： K. W. Kinzler
DOI: 10.1126/SCIENCE.280.5366.1036
关键词: Colorectal cancer 、 Cancer research 、 Gene 、 Landscaping 、 Cancer 、 Tumor suppressor gene 、 Signal transduction 、 Immunology 、 Biology 、 Stromal cell 、 Tumor progression 、 Multidisciplinary
摘要: Colorectal cancer can arise as a result of spontaneous genetic lesions or an inherited defect. In this issue, Howe et al . report that the gene defective in one syndromes is SMAD4 , member key signal transduction pathway. their commentary, Kinzler and Vogelstein add to classification scheme for colorectal cancers groups offending genes "gatekeepers," "caretakers," "landscapers." Landscaping such as have indirect effect on tissue will eventually become cancerous create abnormal microenvironment cells, probably by acting adjacent stromal cells.
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